{"id":53915,"date":"2026-11-09T09:00:00","date_gmt":"2026-11-09T09:00:00","guid":{"rendered":"https:\/\/campusvygon.com\/uk\/?p=53915"},"modified":"2026-10-22T09:47:52","modified_gmt":"2026-10-22T08:47:52","slug":"immediate-skin-to-skin-contact-at-very-preterm-birth-what-does-the-ipistoss-evidence-tell-us","status":"publish","type":"post","link":"https:\/\/campusvygon.com\/uk\/neonatology\/immediate-skin-to-skin-contact-at-very-preterm-birth-what-does-the-ipistoss-evidence-tell-us\/","title":{"rendered":"Immediate Skin-to-Skin Contact at Very Preterm Birth: What Does the IPISTOSS Evidence Tell Us?"},"content":{"rendered":"\n<p class=\"has-medium-font-size wp-block-paragraph\">The benefits of skin-to-skin contact are well established for term and late preterm infants. However, uncertainty has remained regarding its use immediately after very preterm birth, where concerns over cardiorespiratory stability, thermal regulation and the need for intensive monitoring have traditionally favoured incubator-based stabilisation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The Immediate Parent-Infant Skin-To-Skin Study (IPISTOSS) was designed to address this evidence gap by evaluating whether very preterm infants could safely receive immediate and continuous skin-to-skin contact during the first hours after birth, and whether this early intervention influences longer-term developmental and relational outcomes.[1]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Study Design<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">IPISTOSS was a multicentre randomised clinical trial conducted across neonatal units in Norway and Sweden. Infants born between 28+0 and 32+6 weeks&#8217; gestation were randomised to receive either:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Immediate and continuous skin-to-skin contact with a parent for the first six hours after birth, or<\/li>\n\n\n\n<li>Conventional incubator care.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">The study evaluated a broad range of physiological, developmental and psychosocial outcomes, reflecting the growing emphasis on family-integrated care within neonatal services.[1]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Safety and Physiological Adaptation<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">One of the most significant contributions of the IPISTOSS programme is the demonstration that immediate skin-to-skin contact can be implemented safely in selected very preterm infants within neonatal intensive care settings.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Published findings indicate that infants receiving immediate skin-to-skin contact achieved satisfactory cardiorespiratory adaptation and thermal stability, supporting the feasibility of avoiding routine parent-infant separation during the immediate postnatal period when clinically appropriate.[2]<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These findings contribute to a growing body of evidence supporting earlier parental involvement in neonatal stabilisation and care.[2]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Parent-Infant Interaction<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A secondary analysis of the trial examined parent-infant interaction at four months corrected age. Infants who had received immediate skin-to-skin contact demonstrated more favourable interaction patterns than those receiving conventional care.[3]<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study also highlighted the role of fathers and partners in providing early skin-to-skin contact when mothers were unable to do so immediately after birth, reinforcing the value of family-integrated care approaches from the earliest stages of neonatal admission.[2,3]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Stress Regulation and Co-Regulation<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Further follow-up data explored the effects of immediate skin-to-skin contact on infant stress responses. At four months corrected age, infants exposed to immediate skin-to-skin contact demonstrated greater positive emotional engagement during structured social interaction assessments. Investigators also reported evidence of enhanced mother-infant cortisol synchronisation, suggesting improved physiological co-regulation.[4]<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These findings provide additional insight into how early parental contact may influence infant adaptation beyond the neonatal period.[4]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Neurodevelopmental Outcomes<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Longitudinal follow-up to two years corrected age found no significant differences in overall cognitive, motor or social development between groups. However, infants who received immediate skin-to-skin contact demonstrated improved language outcomes after adjustment for parental education and infant sex.[5]<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Although these findings should be interpreted cautiously, they suggest that immediate skin-to-skin care may influence specific developmental domains without affecting broader neurodevelopmental measures.[5]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Implications for Clinical Practice<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">For neonatal teams considering implementation of immediate skin-to-skin stabilisation, the IPISTOSS findings add to an expanding evidence base supporting family-integrated care from birth.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study does not suggest that all very preterm infants should routinely bypass conventional stabilisation pathways. Rather, it demonstrates that immediate skin-to-skin contact can be delivered safely in appropriately selected infants when supported by established protocols, experienced multidisciplinary teams and continuous clinical monitoring.[1,5]<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These findings align with broader efforts to minimise unnecessary parent-infant separation while maintaining high standards of neonatal care and patient safety.[4,5]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Limitations<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">As with any individual research programme, caution is required when generalising findings. The study was conducted within Scandinavian neonatal centres with established family-integrated care models and substantial experience supporting parental participation during stabilisation.[1,5]<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Further research is required to evaluate implementation across different healthcare systems and to better understand the longer-term developmental implications of immediate skin-to-skin contact for very preterm infants.[4,5]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Conclusion<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The IPISTOSS programme provides important evidence that immediate skin-to-skin contact following very preterm birth is both feasible and safe within appropriately structured neonatal services. Beyond physiological stabilisation, published findings suggest potential benefits in parent-infant interaction, infant stress regulation and language development. While further investigation remains warranted, the evidence supports ongoing efforts to reduce unnecessary separation and strengthen family-centred approaches to neonatal care.[2-5]<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<h3 class=\"wp-block-heading\">References<\/h3>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li>Linn\u00e9r A, Westrup B, Lode-Kolz K, Klemming S, Lilliesk\u00f6ld S, Pike HM, et al. Immediate parent-infant skin-to-skin study (IPISTOSS): study protocol of a randomised controlled trial on very preterm infants cared for in skin-to-skin contact immediately after birth and potential physiological, epigenetic, psychological and neurodevelopmental consequences. <em>BMJ Open<\/em>. 2020;10(7):e038938. PMID: 32636292. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32636292\/\" rel=\"nofollow noopener\" target=\"_blank\">[pubmed.ncb&#8230;lm.nih.gov]<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.office.com\/search?q=Jonas+W&amp;EntityRepresentationId=bf8f8236-34a8-8855-9b1d-c092a1dd762a\" rel=\"nofollow noopener\" target=\"_blank\">Jonas W<\/a>, <a href=\"https:\/\/www.office.com\/search?q=Lilliesk%c3%b6ld+S&amp;EntityRepresentationId=98654501-9fe8-8d6a-afda-5e648db2f239\" rel=\"nofollow noopener\" target=\"_blank\">Lilliesk\u00f6ld S<\/a> and colleagues. Early body contact develops premature babies&#8217; social skills. <a href=\"https:\/\/www.office.com\/search?q=Karolinska+Institutet&amp;EntityRepresentationId=3c0939fa-bf37-807e-be59-dba9f276a48b\" rel=\"nofollow noopener\" target=\"_blank\">Karolinska Institutet<\/a>; 2023. Available from: <a href=\"https:\/\/news.ki.se\/early-body-contact-develops-premature-babies-social-skills\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/news.ki.se\/early-body-contact-develops-premature-babies-social-skills<\/a> <a href=\"https:\/\/news.ki.se\/early-body-contact-develops-premature-babies-social-skills\" rel=\"nofollow noopener\" target=\"_blank\">[news.ki.se]<\/a><\/li>\n\n\n\n<li>Lilliesk\u00f6ld S, Lode-Kolz K, Rettedal S, Lindstedt J, Linn\u00e9r A, Pike HM, et al. Skin-to-skin contact at birth for very preterm infants and mother-infant interaction quality at 4 months: a secondary analysis of the IPISTOSS randomised clinical trial. <em>JAMA Network Open<\/em>. 2023;6(11):e2344469. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10690460\/\" rel=\"nofollow noopener\" target=\"_blank\">[pmc.ncbi.nlm.nih.gov]<\/a><\/li>\n\n\n\n<li>Lode-Kolz K, Lilliesk\u00f6ld S, Hetland HB, Klemming S, Jonas W, Rettedal S, et al. Immediate skin-to-skin contact at very preterm birth and effect on infant socio-emotional stress response and mother-infant cortisol co-regulation: secondary outcomes from the randomised clinical Immediate Parent-Infant Skin-To-Skin Study (IPISTOSS). <em>BMJ Paediatrics Open<\/em>. 2026;10(1):e003778. <a href=\"https:\/\/bmjpaedsopen.bmj.com\/content\/10\/1\/e003778\" rel=\"nofollow noopener\" target=\"_blank\">[bmjpaedsopen.bmj.com]<\/a><\/li>\n\n\n\n<li>Lode-Kolz K, Jonas W, Hetland HB, Insteb\u00f8 KHH, Tokvam H, Pike H, et al. Immediate skin-to-skin contact at very preterm birth and neurodevelopment the first two years: secondary outcomes from a randomised clinical trial. <em>Children (Basel)<\/em>. 2025;12(8):986. <a href=\"https:\/\/www.mdpi.com\/2227-9067\/12\/8\/986\" rel=\"nofollow noopener\" target=\"_blank\">[mdpi.com]<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>The benefits of skin-to-skin contact are well established for term and late preterm infants. However, uncertainty has remained regarding its use immediately after very preterm birth, where concerns over cardiorespiratory stability, thermal regulation and the need for intensive monitoring have traditionally favoured incubator-based stabilisation. The Immediate Parent-Infant Skin-To-Skin Study (IPISTOSS) was designed to address this [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":53917,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[18],"tags":[],"class_list":["post-53915","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neonatology"],"acf":[],"_links":{"self":[{"href":"https:\/\/campusvygon.com\/uk\/wp-json\/wp\/v2\/posts\/53915","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/campusvygon.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/campusvygon.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/campusvygon.com\/uk\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/campusvygon.com\/uk\/wp-json\/wp\/v2\/comments?post=53915"}],"version-history":[{"count":4,"href":"https:\/\/campusvygon.com\/uk\/wp-json\/wp\/v2\/posts\/53915\/revisions"}],"predecessor-version":[{"id":53921,"href":"https:\/\/campusvygon.com\/uk\/wp-json\/wp\/v2\/posts\/53915\/revisions\/53921"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/campusvygon.com\/uk\/wp-json\/wp\/v2\/media\/53917"}],"wp:attachment":[{"href":"https:\/\/campusvygon.com\/uk\/wp-json\/wp\/v2\/media?parent=53915"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/campusvygon.com\/uk\/wp-json\/wp\/v2\/categories?post=53915"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/campusvygon.com\/uk\/wp-json\/wp\/v2\/tags?post=53915"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}